SOLVED850

help revised this sentences Pharmacokinetics in obese patients can be influenced by alterations in drug distribution and elimination processes. The standard practice of dosing drugs based on weight or body surface area may not yield optimal safety or efficacy outcomes, particularly in highly obese individuals. Unfortunately, current knowledge about most drugs does not offer adequate guidance for dose adjustments in this patient population. This article discusses the factors that impact the pharmacokinetics of drugs in obese patients, with examples including analgesics, antibiotics, anticoagulants, and others. Given the variability in pharmacokinetics, which cannot always be predicted from the physical and chemical properties of a drug’s molecular structure, it is crucial to evaluate the pharmacokinetic properties of each specific drug rather than seeking universal dosing rules. For drugs with a narrow therapeutic index, such as aminoglycoside antibiotics and vancomycin, anticonvulsants, immunosuppressants, lithium, digoxin, and theophylline, it is recommended to monitor drug plasma levels and employ therapeutic drug monitoring.
SCIENCE
HEALTH SCIENCE
NURSING

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