SOLVED2730

This is a two-part assignment. In a 2-page paper (double spaced, 12pt font times new roman) with two primary citations in-text. Fully characterize MRP1. Specifically, include all relevant facts, including classification of the transporter (primary or secondary active, pore, etc), catalytic cycle, endogenous and xenobiotic substrates, tissue distribution, clinical considerations. 2. Drug X is an MDR substrate that is 100% metabolized by CYP3A4. Drug X is an alkaloid derivative from an evergreen tree found in North America. Drug X has a narrow therapeutic index and is used to treat cancer, given by mouth twice daily. Please decide if a person taking Drug X should avoid Orange Juice during therapy or not. Explain your rationale based on the literature.
SCIENCE
HEALTH SCIENCE
NURSING

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