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Black Box warnings for Tacrolimus Include Black Box warnings for Tacrolimus Include Rare cases of malignancy (e.g., skin; lymphoma) have been reported although a causal relationship has not been established. Long-term safety has not been established. Serious neuropsychiatric events that may include suicidal thoughts or actions have been reported Neurotoxicity, including seizures and death, has been reported with repeat or prolonged application, and rarely with single application. Use with caution in those at risk for neurotoxicity including infants, children, elderly persons, those who weigh <50 kg, or those with a history of seizures Tendinitis, tendon rupture, and worsening of myasthenia gravis/long-term risk SCIENCE HEALTH SCIENCE NURSING

 
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