SOLVED1796

Sipuleucel-T is a dendritic cell-based prostate cancer vaccine designed to elicit enhanced antitumor immune responses in individuals with advanced prostate cancer. The evidence to date indicates that the vaccine is beneficial in reducing the mortality of patients with this disease but determining whether a given individual is responding to the vaccine has been difficult to discern from the usual clinical data obtained. A recent study found one change in patients with sipuleucel-T versus control patients correlated with improved outcomes. What was the most likely cause of this change? increased anti-prostate antigen:antibody titers in the patients’ circulation reduced levels of IDO in the patients’ tumor microenvironments increased numbers of T cells in the patients’ blood increased diversity of TCRs on T cells in the patients’ tumors increased numbers of monocytes and dendritic cells in the patients’ tumors
SCIENCE
HEALTH SCIENCE
NURSING

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