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1. What is the rationale for starting Anne on a biguanide (Metformin) and a Sulfonylurea (Gliclazide)? 2. In the management of type 2 diabetes, patients often require multiple antihyperglycemic agents. Discuss the rationale behind combining different classes of drugs, and what factors would influence the choice of combination therapy for an individual patient? 3. Review Anne’s lab results. Would Anne’s renal function impact the choice and dosing of these medications, and what adjustments should be made to ensure patient safety and efficacy? 4. 3 months after Anne started oral antihyperglycemic therapy, her Hemoglobin A1C is 7.8%. Anne’s physician has decided to start Anne on insulin therapy. Anne is to continue with her current dose of Metformin and discontinue the sulfonylurea. Why did Anne’s physician decide to discontinue the sulfonylurea, and not the Metformin? 5. Anne calls in to the clinic and reports that she has “the flu”. What education would you provide to Anne in regard to managing her blood sugars and antihyperglycemic therapy while ill?
SCIENCE
HEALTH SCIENCE
NURSING

 
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