SOLVED801

In-Class Exercise – Effect Measure Modification Persons with a factor V Leiden mutation are resistant to the anticoagulant effect of activated protein C. The following table describes the incidence of first venous thrombosis (VT) in women ages 15 to 49 years, according to presence of factor V Leiden mutation and the use of oral contraceptives (OC) Case of VT Person-Years Incidence of VT per 10,000 person-years Factor V Leiden Negative No OC use 36 437,870 0.8 Current OC use 84 275,858 3.0 Factor V Leiden Positive No OC use 10 17,515 5.7 Current OC use 25 8,757 28.5 1. Assume that the incidence of first and recurrent VT bear a similar relation to oral contraceptive use and the factor V Leiden mutation. In a 15 to 49 year old woman who develops VT, do the data presented above argue that her factor V Leiden status should be considered in counseling about her future methods of contraception (use the table to help with this interpretation)? Incidence of VT per 10,000 person-years Rate ratio Rate difference per 10,000 person-years Factor V Leiden Negative No OC use 0.8 Current OC use 3.0 2.2 Factor V Leiden Positive No OC use 5.7 Current OC
SCIENCE
HEALTH SCIENCE
NURSING

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