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Explain how one or more of the currently available COVID-19 vaccines work to reduce the incidence and/or severity of COVID-19 infections. Some of the questions you might consider are: Which antigenic epitopes do the current vaccines target? Based on current evidence, how long do SARS-CoV-2 antibodies persist after the primary series compared to a booster dose? Are there differences in immune response depending on how much time elapses between vaccinations?  Are there differences in the immune responses of patients with immune-suppressing conditions?  Is there any evidence that cell-mediated immunity, i.e., T cells, is also affected by vaccination? How have emerging new variants, e.g., omicron, been able to partially evade the immune response induced by the vaccines? How do the recently authorized new bivalent boosters by Moderna and Pfizer work to specifically target current omicron strains more effectively? 

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